Rekombinanter PAK2 Antikörper

Produktnummer ABIN7127664

Produktdetails anti-PAK2 Antikörper

Target: PAK2 (P21-Activated Kinase 2 (PAK2))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser PAK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Flow Cytometry (FACS)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human PAK2

Klon: 6D12

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, FC:1:20-1:200, IP:1:200-1:1000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PAK2

Target: PAK2 (P21-Activated Kinase 2 (PAK2))

Andere Bezeichnung: PAK2 (PAK2 Produkte)

Synonyme: PAK65 antikoerper, PAKgamma antikoerper, gamma-PAK antikoerper, 5330420P17Rik antikoerper, A130002K10Rik antikoerper, AI836325 antikoerper, D16Ertd269e antikoerper, PAK-2 antikoerper, mKIAA4182 antikoerper, pak2 antikoerper, cb422 antikoerper, kinase antikoerper, zgc:91798 antikoerper, wu:fb71h01 antikoerper, si:dz198m22.1 antikoerper, pak65 antikoerper, pakgamma antikoerper, PAKI antikoerper, Pak3 antikoerper, CH73-159L23.1 antikoerper, wu:fc52b03 antikoerper, zgc:113857 antikoerper, p21 (RAC1) activated kinase 2 antikoerper, p21 protein (Cdc42/Rac)-activated kinase 2 antikoerper, p21 protein (Cdc42/Rac)-activated kinase 2a antikoerper, p21 protein (Cdc42/Rac)-activated kinase 2 S homeolog antikoerper, p21 protein (Cdc42/Rac)-activated kinase 2b antikoerper, PAK2 antikoerper, Pak2 antikoerper, pak2a antikoerper, pak2.S antikoerper, pak2b antikoerper

Hintergrund:

Background: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation.

Aliases: Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27), PAK-2p34 (p34) (C-t-PAK2)], PAK2

UniProt: Q13177

Pathways: MAPK Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, Regulation of Lipid Metabolism by PPARalpha