Rekombinanter Topoisomerase I Antikörper
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- Target Alle Topoisomerase I (TOP1) Antikörper anzeigen
- Topoisomerase I (TOP1) (Topoisomerase (DNA) I (TOP1))
- Antikörpertyp
- Recombinant Antibody
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Monoklonal
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Konjugat
- Dieser Topoisomerase I Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Flow Cytometry (FACS)
- Kreuzreaktivität
- Human
- Aufreinigung
- Affinity-chromatography
- Immunogen
- A synthesized peptide derived from human TOP1
- Klon
- 6D8
- Isotyp
- IgG
- Top Product
- Discover our top product TOP1 Primärantikörper
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anti-Topoisomerase (DNA) I (TOP1) (AA 692-765) antibody
TOP1 Reaktivität: Human WB, ELISA, IHC (p) Wirt: Maus Monoclonal 1A1 unconjugated
anti-Topoisomerase (DNA) I (TOP1) antibodyTOP1 Reaktivität: Human WB, IHC, IF, IP Wirt: Kaninchen Monoclonal unconjugated
anti-Topoisomerase (DNA) I (TOP1) antibodyTOP1 Reaktivität: Human, Maus WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Topoisomerase (DNA) I (TOP1) (N-Term) antibodyTOP1 Reaktivität: Human WB, FACS Wirt: Maus Monoclonal 1291CT875-142-166 unconjugated
anti-Topoisomerase (DNA) I (TOP1) (Internal Region) antibodyTOP1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Topoisomerase (DNA) I (TOP1) (AA 1-100) antibodyTOP1 Reaktivität: Human WB, IHC, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Topoisomerase (DNA) I (TOP1) (AA 2-31), (N-Term) antibodyTOP1 Reaktivität: Human WB, IF Wirt: Kaninchen Polyclonal RB34034 unconjugated
anti-Topoisomerase (DNA) I (TOP1) (AA 358-501) antibodyTOP1 Reaktivität: Human ELISA, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Topoisomerase (DNA) I (TOP1) antibodyTOP1 Reaktivität: Human, Ratte WB, FACS Wirt: Maus Monoclonal 1C6 unconjugated
anti-Topoisomerase (DNA) I (TOP1) (AA 692-765) antibodyTOP1 Reaktivität: Human WB, ELISA Wirt: Maus Polyclonal unconjugated
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- Applikationshinweise
- Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, FC:1:20-1:200, IP:1:200-1:1000,
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- Topoisomerase I (TOP1) (Topoisomerase (DNA) I (TOP1))
- Andere Bezeichnung
- TOP1 (TOP1 Produkte)
- Substanzklasse
- Viral Protein
- Hintergrund
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Background: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component ARNTL/BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the ARNTL/BMAL1 promoter.
Aliases: DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I), TOP1
- UniProt
- P11387
- Pathways
- Caspase Kaskade in der Apoptose, Stem Cell Maintenance
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