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Rekombinanter TRAF2 Antikörper

TRAF2 Reaktivität: Human WB, ELISA, IHC, IP, FACS Wirt: Kaninchen Monoclonal 9A5 unconjugated Recombinant Antibody
Produktnummer ABIN7127853
  • Target Alle TRAF2 Antikörper anzeigen
    TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))
    Antikörpertyp
    Recombinant Antibody
    Reaktivität
    • 92
    • 30
    • 29
    • 1
    • 1
    Human
    Wirt
    • 76
    • 16
    • 1
    • 1
    Kaninchen
    Klonalität
    • 70
    • 24
    Monoklonal
    Konjugat
    • 41
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TRAF2 Antikörper ist unkonjugiert
    Applikation
    • 67
    • 32
    • 19
    • 19
    • 16
    • 15
    • 14
    • 13
    • 10
    • 9
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Flow Cytometry (FACS)
    Kreuzreaktivität
    Human
    Aufreinigung
    Affinity-chromatography
    Immunogen
    A synthesized peptide derived from human TRAF2
    Klon
    9A5
    Isotyp
    IgG
    Top Product
    Discover our top product TRAF2 Primärantikörper
  • Applikationshinweise
    Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, FC:1:20-1:200, IP:1:200-1:1000,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))
    Andere Bezeichnung
    TRAF2 (TRAF2 Produkte)
    Synonyme
    MGC:45012 antikoerper, TRAP antikoerper, TRAP3 antikoerper, TANK antikoerper, AI325259 antikoerper, TNF-receptor-associated factor 2 antikoerper, conjugal transfer protein TraF antikoerper, TNF receptor associated factor 2 antikoerper, TNF receptor-associated factor 2 antikoerper, Tnf receptor-associated factor 2 antikoerper, LOC661716 antikoerper, traF2 antikoerper, TRAF2 antikoerper, Traf2 antikoerper
    Hintergrund

    Background: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation, this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.

    Aliases: TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3), TRAF2, TRAP3

    UniProt
    Q12933
    Pathways
    NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response, S100 Proteine
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