Rekombinanter VCP Antikörper

Produktnummer ABIN7127867

Produktdetails anti-VCP Antikörper

Target: VCP (Valosin Containing Protein (VCP))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser VCP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Kreuzreaktivität: Human, Ratte

Aufreinigung: Affinity-chromatography

Immunogen: A synthesized peptide derived from human VCP

Klon: 5H12

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200, IF:1:20-1:200, IP:1:200-1:1000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu VCP

Target: VCP (Valosin Containing Protein (VCP))

Andere Bezeichnung: VCP (VCP Produkte)

Synonyme: ALS14 antikoerper, IBMPFD antikoerper, TERA antikoerper, p97 antikoerper, CDC48 antikoerper, wu:fd16d05 antikoerper, wu:fj63d11 antikoerper, p93 antikoerper, 3110001E05 antikoerper, p97/VCP antikoerper, 22.26 antikoerper, 7.12 antikoerper, Apple antikoerper, BcDNA.GM02885 antikoerper, BcDNA:GM02885 antikoerper, CG2331 antikoerper, DmTER94 antikoerper, Dmel\CG2331 antikoerper, I antikoerper, Ter94 antikoerper, Tera antikoerper, VCP antikoerper, VCP ATPase antikoerper, VCP/p97 antikoerper, Vcp antikoerper, anon-WO2004063362.65 antikoerper, anon-WO2004063362.67 antikoerper, cdc48 antikoerper, dTERA antikoerper, dVCP antikoerper, dmTERA antikoerper, dvcp antikoerper, l(2)03775 antikoerper, l(2)46CFf antikoerper, l(2)46CFs antikoerper, l(2)46Ch antikoerper, pTER94 antikoerper, ter94 antikoerper, vcp antikoerper, FANCG antikoerper, valosin containing protein antikoerper, valosin containing protein S homeolog antikoerper, valosin-containing protein antikoerper, CG2331 gene product from transcript CG2331-RA antikoerper, zgc:136908 antikoerper, transitional endoplasmic reticulum ATPase antikoerper, VCP antikoerper, vcp.S antikoerper, vcp antikoerper, Vcp antikoerper, Bm1_56585 antikoerper, LOC100136246 antikoerper, TER94 antikoerper, zgc:136908 antikoerper, LOC101109680 antikoerper

Hintergrund:

Background: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites (PubMed:22020440, PubMed:22120668). Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (PubMed:23042607, PubMed:23042605). Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation (PubMed:16186510, PubMed:21118995). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022). Acts as a negative regulator of type I interferon production by interacting with DDX58/RIG-I: interaction takes place when DDX58/RIG-I is ubiquitinated via 'Lys-63'-linked ubiquitin on its CARD domains, leading to recruit RNF125 and promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729).

Aliases: Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP), VCP

UniProt: P55072

Pathways: ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Ubiquitin Proteasome Pathway