GABRA3 Antikörper

Produktnummer ABIN7137967

Produktdetails anti-GABRA3 Antikörper

Target: GABRA3 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GABRA3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide

Immunogen: Peptide sequence around aa. 33~37(R-R-Q-E-P)derived from Rat GABA A Receptor a3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu GABRA3

Target: GABRA3 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3))

Andere Bezeichnung: Gabra3 (GABRA3 Produkte)

Synonyme: GABRA3 antikoerper, Gabra-3 antikoerper, si:ch211-113k9.1 antikoerper, gamma-aminobutyric acid type A receptor alpha3 subunit antikoerper, gamma-aminobutyric acid (GABA) A receptor, alpha 3 antikoerper, gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3 antikoerper, gamma-aminobutyric acid receptor subunit alpha-3 antikoerper, GABRA3 antikoerper, gabra3 antikoerper, Gabra3 antikoerper, LOC100653496 antikoerper

Hintergrund:

Background: GABA (g-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The ionotropic GABA(A) and GABA(C) receptors are ligand-gated ion channels that produce fast inhibitory synaptic transmission. In contrast, the metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission (1). Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site (2). Two isoforms of GABA(B)R1 have been cloned: GABA(B)R1a is a 130 kD protein and GABA(B)R1b is a 95 kD protein (3). G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA(B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA(B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsynaptic GABA(B) receptors inhibit through coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition, GABA(B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation (1).

Jones, K.A. et al. (2000) Neuropsychopharmacology 23, S41-9.
Duthey, B. et al. (2002) J Biol Chem 277, 3236-41.
Kaupmann, K. et al. (1997) Nature 386, 239-46.

Aliases: Gabra3 antibody, Gabra-3 antibody, Gamma-aminobutyric acid receptor subunit alpha-3 antibody, GABA(A) receptor subunit alpha-3 antibody

UniProt: P20236