EIF4G1 Antikörper (pSer1232)

Produktnummer ABIN7138417

Produktdetails anti-EIF4G1 Antikörper

Target: EIF4G1 (Eukaryotic Translation Initiation Factor 4 Gamma, 1 (EIF4G1))

Bindungsspezifität: pSer1232

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EIF4G1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), ELISA

Kreuzreaktivität: Human

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of serine 1232 (P-V-S(p)-P-L) derived from Human eIF4G.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000, IHC:1:50-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu EIF4G1

Target: EIF4G1 (Eukaryotic Translation Initiation Factor 4 Gamma, 1 (EIF4G1))

Andere Bezeichnung: EIF4G1 (EIF4G1 Produkte)

Synonyme: EIF4GI antikoerper, CG10811 antikoerper, Dmel\\CG10811 antikoerper, EIF4G antikoerper, Eif4G antikoerper, deIF4G antikoerper, eIF-4G antikoerper, eIF4g antikoerper, p200 antikoerper, EIF4G1 antikoerper, wu:fb50a05 antikoerper, wu:fc60b06 antikoerper, eif4g antikoerper, CUCUMOVIRUS MULTIPLICATION 2 antikoerper, CUM2 antikoerper, EUKARYOTIC TRANSLATION INITIATION FACTOR 4G antikoerper, eukaryotic translation initiation factor 4G antikoerper, DDBDRAFT_0217646 antikoerper, DDBDRAFT_0217647 antikoerper, DDBDRAFT_0234257 antikoerper, DDB_0217646 antikoerper, DDB_0217647 antikoerper, DDB_0234257 antikoerper, NV18824 antikoerper, EIF-4G1 antikoerper, EIF4F antikoerper, P220 antikoerper, PARK18 antikoerper, p220 antikoerper, E030015G23Rik antikoerper, eIF4GI antikoerper, eukaryotic translation initiation factor 4 gamma 1 antikoerper, eukaryotic translation initiation factor 4G antikoerper, eukaryotic translation initiation factor 4 gamma, 1a antikoerper, eukaryotic translation initiation factor 4 gamma, 1 S homeolog antikoerper, eukaryotic initiation factor antikoerper, eukaryotic translation initiation factor 4 gamma antikoerper, eukaryotic translation initiation factor 4 gamma, 1 antikoerper, eukaryotic translation initiation factor 4, gamma 1 antikoerper, EIF4G1 antikoerper, eIF4G antikoerper, eif4g1a antikoerper, LOC704923 antikoerper, eif4g1.S antikoerper, EIF4G antikoerper, eIF4g antikoerper, Eif4g antikoerper, Eif4g1 antikoerper

Hintergrund:

Background: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E, insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin stimulation mediated by FKBPs. Interacts with EIF4E3. Interacts with MIF4GD. Interacts with rotavirus A NSP3, in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis

De Gregorio, E. et al. (1998) RNA 4, 828-836.
Ohlmann, T. et al. (1996) EMBO J. 15, 1371-1382.
Borman, A.M. and Kean, K.M. (1997) Virology 237, 129-136.
Gradi, A. et al. (1998) Mol Cell Biol 18, 334-42.

Aliases: DKFZp686A1451 antibody, eIF 4 gamma 1 antibody, eIF 4G 1 antibody, eIF 4G1 antibody, eIF-4-gamma 1 antibody, eIF-4G 1 antibody, eIF-4G1 antibody, EIF4 gamma antibody, EIF4F antibody, EIF4G antibody, EIF4G1 antibody, EIF4GI antibody, Eukaryotic translation initiation factor 4 gamma 1 antibody, IF4G1_HUMAN antibody, p220 antibody

UniProt: Q04637