PAK2 Antikörper (pSer197)

Produktnummer ABIN7138464

Produktdetails anti-PAK2 Antikörper

Target: PAK2 (P21-Activated Kinase 2 (PAK2))

Bindungsspezifität: pSer197

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAK2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of Serine 197(T-R-S(p)-V-I) derived from Human PAK2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC:1:50-1:100,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PAK2

Target: PAK2 (P21-Activated Kinase 2 (PAK2))

Andere Bezeichnung: PAK2 (PAK2 Produkte)

Hintergrund:

Background:

The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

Martin G.A., EMBO J. 14:1970-1978(1995).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Olsen J.V., Cell 127:635-648(2006).

Aliases: C-t-PAK2 antibody, CB422 antibody, EC 2.7.11.1 antibody, Gamma PAK antibody, Gamma-PAK antibody, hPAK65 antibody, Kinase antibody, p21 (CDKN1A) activated kinase 2 antibody, p21 (CDKN1A)-activated kinase 2a antibody, p21 activated kinase 2 antibody, p21 protein (Cdc42/Rac)-activated kinase 2 antibody, p21 protein Cdc42 Rac activated kinase 2 antibody, p21-activated kinase 2 antibody, p21-activated kinase, 65-KD antibody, p21-activated protein kinase I antibody, p21CDKN1A activated kinase 2 antibody, p27 antibody, p34 antibody, p58 antibody, p65PAK antibody, PAK 2 antibody, PAK-2 antibody, PAK-2p34 antibody, Pak2 antibody, PAK2_HUMAN antibody, PAK65 antibody, PAKgamma antibody, S6 H4 kinase antibody, S6/H4 kinase antibody, Serine threonine protein kinase PAK 2 antibody, Serine/threonine protein kinase PAK 2 antibody

UniProt: Q13177

Pathways: MAPK Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, Regulation of Lipid Metabolism by PPARalpha