EIF2S1 Antikörper (pSer49)

Produktnummer ABIN7138634

Produktdetails anti-EIF2S1 Antikörper

Target: EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1))

Bindungsspezifität: pSer49

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EIF2S1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of Serine 49 (L-L-S(p)-E-L) derived from Human eIF2a.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu EIF2S1

Target: EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1))

Andere Bezeichnung: EIF2S1 (EIF2S1 Produkte)

Synonyme: EIF-2 antikoerper, EIF-2A antikoerper, EIF-2alpha antikoerper, EIF2 antikoerper, EIF2A antikoerper, Eif2s1 antikoerper, eif2s1l antikoerper, fb36a08 antikoerper, wu:fb36a08 antikoerper, zgc:56510 antikoerper, 0910001O23Rik antikoerper, 2410026C18Rik antikoerper, 35kDa antikoerper, Eif2a antikoerper, eIF2alpha antikoerper, eif2a antikoerper, CG9946 antikoerper, Dmel\\CG9946 antikoerper, Eif2alpha antikoerper, IF2A_DROME antikoerper, M(1)14C antikoerper, M(1)19-153 antikoerper, M(1)8e3-10 antikoerper, deIF2alpha antikoerper, eIF-2 antikoerper, eIF-2 a antikoerper, eIF-2 alpha antikoerper, eIF2 alpha antikoerper, eIF2-alpha antikoerper, eIF2a antikoerper, eiF-2alpha antikoerper, elF2alpha antikoerper, l(1)14Cf antikoerper, l(1)19-153 antikoerper, eukaryotic translation initiation factor 2 subunit alpha antikoerper, eukaryotic translation initiation factor 2, subunit 1 alpha a antikoerper, eukaryotic translation initiation factor 2, subunit 1 alpha antikoerper, eukaryotic translation initiation factor 2 alpha subunit antikoerper, Eukaryotic translation initiation factor 2 subunit 1 antikoerper, eukaryotic translation initiation factor 2 subunit alpha L homeolog antikoerper, eukaryotic translation Initiation Factor 2alpha antikoerper, EIF2S1 antikoerper, eif2s1a antikoerper, Eif2s1 antikoerper, eif2s1 antikoerper, LOC693063 antikoerper, CNI00230 antikoerper, THAPSDRAFT_105 antikoerper, if2a antikoerper, eif2s1.L antikoerper, eIF-2alpha antikoerper

Hintergrund:

Background:

Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Kimball, S.R. (1999) Int. J. Biochem. Cell Biol. 31, 25-29.
De Haro, C. et al. (1996) FASEB J. 10, 1378-1387.
Sheikh, M.S. and Fornace Jr., A.J. (1999) Oncogene 18, 6121-6128.
Cheshire, J.L. et al. (1999) J. Biol. Chem. 274, 4801-4806.

Aliases: EIF 2 alpha antibody, EIF 2 antibody, EIF 2A antibody, EIF 2alpha antibody, eIF-2-alpha antibody, eIF-2A antibody, EIF-2alpha antibody, EIF2 alpha antibody, EIF2 antibody, EIF2A antibody, EIF2S1 antibody, Eukaryotic translation initiation factor 2 subunit 1 alpha 35 kDa antibody, Eukaryotic translation initiation factor 2 subunit 1 alpha antibody, Eukaryotic translation initiation factor 2 subunit 1 antibody, Eukaryotic translation initiation factor 2 subunit alpha antibody, IF2A_HUMAN antibody

UniProt: P05198

Pathways: Ribonucleoprotein Complex Subunit Organization, ER-Nucleus Signaling, Hepatitis C