STK4 Antikörper (pThr183)
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- Target Alle STK4 Antikörper anzeigen
- STK4 (serine/threonine Kinase 4 (STK4))
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Bindungsspezifität
- pThr183
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser STK4 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Kreuzreaktivität
- Human, Maus
- Aufreinigung
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
- Immunogen
- Peptide sequence around phosphorylation site of threonine 183 (R-N-T(p)-V-I) derived from Human Mst1/2.
- Isotyp
- IgG
- Top Product
- Discover our top product STK4 Primärantikörper
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- Applikationshinweise
- WB:1:500-1:3000, IHC:1:50-1:100,
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- STK4 (serine/threonine Kinase 4 (STK4))
- Andere Bezeichnung
- STK4 (STK4 Produkte)
- Synonyme
- KRS2 antikoerper, MST1 antikoerper, TIIAC antikoerper, YSK3 antikoerper, AI447339 antikoerper, AU020804 antikoerper, Kas-2 antikoerper, Mst1 antikoerper, Ysk3 antikoerper, krs2 antikoerper, mst1 antikoerper, ysk3 antikoerper, serine/threonine kinase 4 antikoerper, serine/threonine kinase 4 S homeolog antikoerper, STK4 antikoerper, Stk4 antikoerper, stk4.S antikoerper
- Hintergrund
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Background: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation By similarity.
Aliases: Kinase responsive to stress antibody, Krs2 antibody, Mammalian STE20 like protein kinase 1 antibody, Mammalian STE20-like protein kinase 1 antibody, Mammalian sterile 20 like 1 antibody, MST-1 antibody, MST1 antibody, Serine/threonine kinase 4 antibody, Serine/threonine protein kinase Krs 2 antibody, Serine/threonine-protein kinase 4 antibody, Serine/threonine-protein kinase Krs-2 antibody, STE20 like kinase MST1 antibody, STE20-like kinase MST1 antibody, STK4 antibody, STK4_HUMAN antibody, TIIAC antibody, YSK3 antibody
- UniProt
- Q13043
- Pathways
- Tube Formation
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