PIK3R1/PIK3R3 Antikörper (pTyr467)

Produktnummer ABIN7139011

Produktdetails anti-PIK3R1/PIK3R3 Antikörper

Target: PIK3R1/PIK3R3 (PIK3R3A) (Phosphoinositide-3-Kinase, Regulatory Subunit 3a (Gamma) (PIK3R3A))

Bindungsspezifität: pTyr467

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIK3R1/PIK3R3 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 467 (L-Y(p)-E-E-Y) derived from Human PI3 Kinase p85/p55.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu PIK3R1/PIK3R3

Target: PIK3R1/PIK3R3 (PIK3R3A) (Phosphoinositide-3-Kinase, Regulatory Subunit 3a (Gamma) (PIK3R3A))

Andere Bezeichnung: PIK3R1/PIK3R3 (PIK3R3A Produkte)

Synonyme: wu:fb16a12 antikoerper, wu:fk56b03 antikoerper, zgc:73230 antikoerper, phosphoinositide-3-kinase, regulatory subunit 3a (gamma) antikoerper, pik3r3a antikoerper

Hintergrund:

Background:

Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1./Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.

Stoyanov, B. et al. (1995) Science 269, 690-3.
Simpson, L. and Parsons, R. (2001) Exp Cell Res 264, 29-41.
Neri, L.M. et al. (2002) Biochim Biophys Acta 1584, 73-80.

Aliases: p85, AGM7, p85-ALPHA, p55, p55-GAMMA

UniProt: P27986, Q92569