EPH Receptor A4 Antikörper (pTyr596)

Produktnummer ABIN7139033

Produktdetails anti-EPH Receptor A4 Antikörper

Target: EPH Receptor A4 (EPHA4)

Bindungsspezifität: pTyr596

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPH Receptor A4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Human, Maus

Aufreinigung: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 596 (R-T-Y(p)-V-D) derived from Human EPHA4 .

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:1000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu EPH Receptor A4

Target: EPH Receptor A4 (EPHA4)

Andere Bezeichnung: EPHA4 (EPHA4 Produkte)

Hintergrund:

Background:

Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity.

Rikova K., Cell 131:1190-1203(2007) [PubMed: 18083107].
Richter M., J. Neurosci. 27:14205-14215(2007) [PubMed: 18094260].
Fu W.Y., Nat. Neurosci. 10:67-76(2007) [PubMed: 17143272].

Aliases: Cek 8 antibody, CEK8 antibody, EK8 antibody, eph receptor a4 antibody, EPH-like kinase 8 antibody, EPHA4 antibody, EPHA4_HUMAN antibody, Ephrin type-A receptor 4 antibody, HEK 8 antibody, hEK8 antibody, Receptor protein-tyrosine kinase HEK8 antibody, Sek 1 antibody, SEK antibody, TYRO 1 protein tyrosine kinase antibody, TYRO1 antibody, Tyrosine-protein kinase receptor SEK antibody, Tyrosine-protein kinase TYRO1 antibody

UniProt: P54764

Pathways: RTK Signalweg