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DCLRE1B Antikörper (AA 345-493)

DCLRE1B Reaktivität: Human ELISA, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7142656
  • Target Alle DCLRE1B Antikörper anzeigen
    DCLRE1B (DNA Cross-Link Repair 1B (DCLRE1B))
    Bindungsspezifität
    • 7
    • 6
    • 6
    • 6
    • 3
    • 1
    • 1
    • 1
    AA 345-493
    Reaktivität
    • 27
    • 9
    • 1
    Human
    Wirt
    • 26
    • 1
    Kaninchen
    Klonalität
    • 26
    • 1
    Polyklonal
    Konjugat
    • 8
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DCLRE1B Antikörper ist unkonjugiert
    Applikation
    • 18
    • 16
    • 13
    • 2
    • 1
    ELISA, Immunofluorescence (IF)
    Kreuzreaktivität
    Human
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human 5' exonuclease Apollo protein (345-493AA)
    Isotyp
    IgG
    Top Product
    Discover our top product DCLRE1B Primärantikörper
  • Applikationshinweise
    Recommended dilution: IF:1:50-1:200,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    DCLRE1B (DNA Cross-Link Repair 1B (DCLRE1B))
    Andere Bezeichnung
    DCLRE1B (DCLRE1B Produkte)
    Synonyme
    APOLLO antikoerper, SNM1B antikoerper, SNMIB antikoerper, im:6894074 antikoerper, zgc:154089 antikoerper, AI452214 antikoerper, Apollo antikoerper, mSNM1B antikoerper, DNA cross-link repair 1B antikoerper, DCLRE1B antikoerper, Dclre1b antikoerper, dclre1b antikoerper
    Hintergrund

    Background: 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.

    Aliases: DCLRE1B antibody, SNM1B5' exonuclease Apollo antibody, EC 3.1.-.- antibody, DNA cross-link repair 1B protein antibody, SNM1 homolog B antibody, SNMIB antibody, hSNM1B antibody

    UniProt
    Q9H816
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