AP2A2 Antikörper (AA 590-939)
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- Target Alle AP2A2 Antikörper anzeigen
- AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))
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Bindungsspezifität
- AA 590-939
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser AP2A2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Kreuzreaktivität
- Human, Maus
- Aufreinigung
- Antigen Affinity Purified
- Immunogen
- Recombinant Human AP-2 complex subunit alpha-2 protein (590-939AA)
- Isotyp
- IgG
- Top Product
- Discover our top product AP2A2 Primärantikörper
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- Applikationshinweise
- Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- AP2A2 (Adaptor-Related Protein Complex 2, alpha 2 Subunit (AP2A2))
- Andere Bezeichnung
- AP2A2 (AP2A2 Produkte)
- Synonyme
- MGC99219 antikoerper, ADTAB antikoerper, CLAPA2 antikoerper, HIP-9 antikoerper, HIP9 antikoerper, HYPJ antikoerper, 2410074K14Rik antikoerper, AF006990 antikoerper, AW146353 antikoerper, Adtab antikoerper, C78001 antikoerper, L25 antikoerper, adaptor related protein complex 2 alpha 2 subunit antikoerper, adaptor related protein complex 2 alpha 2 subunit L homeolog antikoerper, adaptor-related protein complex 2, alpha 2 subunit antikoerper, AP2A2 antikoerper, ap2a2.L antikoerper, Ap2a2 antikoerper
- Hintergrund
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Background: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity).
Aliases: 100 kDa coated vesicle protein C antibody, Adaptor protein complex AP-2 subunit alpha-2 antibody, Adaptor-related protein complex 2 subunit alpha-2 antibody, Alpha-adaptin C antibody, Alpha2-adaptin antibody, AP-2 complex subunit alpha-2 antibody, Ap2a2 antibody, AP2A2_HUMAN antibody, Clathrin assembly protein complex 2 alpha-C large chain antibody, HIP-9 antibody, Huntingtin yeast partner J antibody, Huntingtin-interacting protein 9 antibody, Huntingtin-interacting protein J antibody, Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit antibody
- UniProt
- O94973
- Pathways
- EGFR Signaling Pathway, Neurotrophin Signalübertragung, EGFR Downregulation, SARS-CoV-2 Protein Interaktom
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