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AAK1 Antikörper (AA 274-465)

AAK1 Reaktivität: Human WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7144390
  • Target Alle AAK1 Antikörper anzeigen
    AAK1 (AP2 associated kinase 1 (AAK1))
    Bindungsspezifität
    • 15
    • 9
    • 8
    • 6
    • 6
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 274-465
    Reaktivität
    • 43
    • 38
    • 13
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human
    Wirt
    • 62
    • 4
    • 1
    Kaninchen
    Klonalität
    • 64
    • 3
    Polyklonal
    Konjugat
    • 33
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser AAK1 Antikörper ist unkonjugiert
    Applikation
    • 42
    • 29
    • 19
    • 13
    • 13
    • 7
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    Kreuzreaktivität
    Human, Maus
    Aufreinigung
    >95%, Protein G purified
    Immunogen
    Recombinant Human AP2-associated protein kinase 1 protein (274-465AA)
    Isotyp
    IgG
    Top Product
    Discover our top product AAK1 Primärantikörper
  • Applikationshinweise
    Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    AAK1 (AP2 associated kinase 1 (AAK1))
    Andere Bezeichnung
    AAK1 (AAK1 Produkte)
    Synonyme
    5530400K14Rik antikoerper, 9630042K20 antikoerper, AU067724 antikoerper, AU067726 antikoerper, BC028270 antikoerper, C79663 antikoerper, D6Ertd245e antikoerper, R75501 antikoerper, mKIAA1048 antikoerper, RGD1563580 antikoerper, aak1 antikoerper, si:dkey-261l11.5 antikoerper, AP2 associated kinase 1 antikoerper, uncharacterized protein FLJ45252 antikoerper, AP2 associated kinase 1b antikoerper, AAK1 antikoerper, Aak1 antikoerper, LOC100512341 antikoerper, aak1b antikoerper
    Hintergrund

    Background: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.

    Aliases: AAK 1 antibody, Aak1 antibody, AAK1_HUMAN antibody, Adaptor associated kinase 1 antibody, Adaptor-associated kinase 1 antibody, AP2 associated kinase 1 antibody, AP2 associated protein kinase 1 antibody, AP2-associated protein kinase 1 antibody, DKFZp686F03202 antibody, DKFZp686K16132 antibody, FLJ23712 antibody, FLJ25931 antibody, FLJ31060 antibody, FLJ42882 antibody, FLJ45252 antibody, KIAA1048 antibody, MGC138170 antibody, MGC164568 antibody, MGC164570 antibody

    UniProt
    Q2M2I8
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