Aurora A Antikörper (AA 1-131)

Produktnummer ABIN7145075

Produktdetails anti-Aurora A Antikörper

Target: Aurora A (AURKA) (Aurora Kinase A (AURKA))

Bindungsspezifität: AA 1-131

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Aurora A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human, Maus

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Aurora kinase A protein (1-131AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu Aurora A

Target: Aurora A (AURKA) (Aurora Kinase A (AURKA))

Andere Bezeichnung: AURKA (AURKA Produkte)

Hintergrund:

Background: Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.

Aliases: AIK antibody, ARK-1 antibody, ARK1 antibody, AURA antibody, Aurka antibody, Aurora 2 antibody, Aurora A antibody, Aurora kinase A antibody, Aurora-related kinase 1 antibody, Aurora/IPL1 like kinase antibody, AURORA/IPL1-like kinase antibody, Aurora/IPL1-related kinase 1 antibody, AURORA2 antibody, Breast tumor-amplified kinase antibody, BTAK antibody, hARK1 antibody, IAK antibody, IPL1 related kinase antibody, MGC34538 antibody, OTTHUMP00000031340 antibody, OTTHUMP00000031341 antibody, OTTHUMP00000031342 antibody, OTTHUMP00000031343 antibody, OTTHUMP00000031344 antibody, OTTHUMP00000031345 antibody, OTTHUMP00000166071 antibody, OTTHUMP00000166072 antibody, PPP1R47 antibody, Protein phosphatase 1, regulatory subunit 47 antibody, Serine/threonine kinase 15 antibody, Serine/threonine kinase 6 antibody, Serine/threonine protein kinase 15 antibody, Serine/threonine-protein kinase 15 antibody, Serine/threonine-protein kinase 6 antibody, Serine/threonine-protein kinase aurora-A antibody, STK15 antibody, STK6 antibody, STK6_HUMAN antibody, STK7 antibody

UniProt: O14965

Pathways: Zellzyklus, Asymmetric Protein Localization