B-Cell Linker Antikörper (AA 41-337)

Produktnummer ABIN7145158

Produktdetails anti-B-Cell Linker Antikörper

Target: B-Cell Linker (BLNK)

Bindungsspezifität: AA 41-337

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser B-Cell Linker Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human B-cell linker protein (41-337AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu B-Cell Linker

Target: B-Cell Linker (BLNK)

Andere Bezeichnung: BLNK (BLNK Produkte)

Synonyme: BLNK antikoerper, blnk antikoerper, MGC147045 antikoerper, BASH antikoerper, Bca antikoerper, Ly-57 antikoerper, Ly57 antikoerper, Lyw-57 antikoerper, SLP-65 antikoerper, AGM4 antikoerper, BLNK-S antikoerper, LY57 antikoerper, SLP65 antikoerper, bca antikoerper, B-cell linker antikoerper, B cell linker antikoerper, BLNK antikoerper, blnk antikoerper, Blnk antikoerper

Hintergrund:

Background: Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.

Aliases: AGM4 antibody, B cell adapter containing SH2 domain protein antibody, B cell adapter containing Src homology 2 domain protein antibody, B cell adaptor containing SH2 domain antibody, B cell linker antibody, B cell linker protein antibody, B cell-specific adaptor protein antibody, B-cell activation antibody, B-cell adapter containing a SH2 domain protein antibody, B-cell adapter containing a Src homology 2 domain protein antibody, B-cell linker protein antibody, BASH antibody, Bca antibody, BLNK antibody, BLNK s antibody, BLNK_HUMAN antibody, Cytoplasmic adapter protein antibody, Ly 57 antibody, Ly57 antibody, Lymphocyte antigen 57 antibody, Lyw 57 antibody, Lyw57 antibody, MGC111051 antibody, SH2 domain-containing leukocyte protein, 65-KD antibody, SLP 65 antibody, SLP-65 antibody, SLP65 antibody, Src homology [SH2] domain-containing leukocyte protein of 65 kD antibody, Src homology 2 domain containing leukocyte protein of 65 kDa antibody, Src homology 2 domain-containing leukocyte protein of 65 kDa antibody

UniProt: Q8WV28

Pathways: BCR Signaling