NAIP Antikörper (AA 147-242) (Biotin)

Produktnummer ABIN7145195

Produktdetails anti-NAIP Antikörper (Biotin)

Target: NAIP (NLR Family, Apoptosis Inhibitory Protein (NAIP))

Bindungsspezifität: AA 147-242

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NAIP Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Baculoviral IAP repeat-containing protein 1 protein (147-242AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu NAIP

Target: NAIP (NLR Family, Apoptosis Inhibitory Protein (NAIP))

Andere Bezeichnung: NAIP (NAIP Produkte)

Synonyme: BIRC1 antikoerper, NLRB1 antikoerper, psiNAIP antikoerper, AV364616 antikoerper, Birc1a antikoerper, D13Lsd1 antikoerper, Naip antikoerper, Naip-rs1 antikoerper, NLR family apoptosis inhibitory protein antikoerper, NLR family, apoptosis inhibitory protein 1 antikoerper, NAIP antikoerper, Naip1 antikoerper

Hintergrund:

Background: \\\"Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at \\\'Asp-315\\\' and decreasing the rate of auto proteolysis at \\\'Asp-330\\\'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy. Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.\\\"

Aliases: Baculoviral IAP repeat containing 1 antibody, Baculoviral IAP repeat-containing protein 1 antibody, BIRC 1 antibody, BIRC1 antibody, BIRC1_HUMAN antibody, Birc1a antibody, FLJ42520 antibody, NAIP antibody, Naip1 antibody, Neuronal apoptosis inhibitory protein antibody, NLR family apoptosis inhibitory protein antibody, NLR family BIR domain containing 1 antibody, NLRB 1 antibody, NLRB1 antibody, Nucleotide binding oligomerization domain leucine rich repeat and BIR domain containing 1 antibody, Psi neuronal apoptosis inhibitory protein antibody, psiNAIP antibody, Similar to occludin antibody

UniProt: Q13075

Pathways: Apoptose, Inflammasome