BBS1 Antikörper (AA 217-417)

Produktnummer ABIN7145231

Produktdetails anti-BBS1 Antikörper

Target: BBS1 (Bardet-Biedl Syndrome 1 (BBS1))

Bindungsspezifität: AA 217-417

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BBS1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human, Maus

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Bardet-Biedl syndrome 1 protein (217-417AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu BBS1

Target: BBS1 (Bardet-Biedl Syndrome 1 (BBS1))

Andere Bezeichnung: BBS1 (BBS1 Produkte)

Synonyme: im:7144669 antikoerper, bbs2l2 antikoerper, BBS1 antikoerper, DKFZp468B1612 antikoerper, BBS2L2 antikoerper, AI451249 antikoerper, D19Ertd609e antikoerper, Bardet-Biedl syndrome 1 antikoerper, bardet-biedl syndrome 1 antikoerper, Bardet-Biedl syndrome 1 (human) antikoerper, BBS1 antikoerper, bbs1 antikoerper, Bbs1 antikoerper

Hintergrund:

Background: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.

Aliases: AI451249 antibody, Bardet-Biedl syndrome 1 antibody, Bardet-Biedl syndrome 1 homolog antibody, Bardet-Biedl syndrome 1 protein antibody, BBS1 antibody, BBS1_HUMAN antibody, BBS2-like protein 2 antibody, BBS2L2 antibody, D19Ertd609e antibody

UniProt: Q8NFJ9

Pathways: Hedgehog Signalweg