BARD1 Antikörper (AA 428-777)

Produktnummer ABIN7145762

Produktdetails anti-BARD1 Antikörper

Target: BARD1 (BRCA1 Associated RING Domain 1 (BARD1))

Bindungsspezifität: AA 428-777

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BARD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human BRCA1-associated RING domain protein 1 protein (428-777AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu BARD1

Target: BARD1 (BRCA1 Associated RING Domain 1 (BARD1))

Andere Bezeichnung: BARD1 (BARD1 Produkte)

Synonyme: BARD1 antikoerper, LOC100147913 antikoerper, ENSMUSG00000060893 antikoerper, ENSMUSG00000073653 antikoerper, BRCA1 associated RING domain 1 antikoerper, BARD1 antikoerper, bard1 antikoerper, Bard1 antikoerper

Hintergrund:

Background: E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of \'Lys-6\'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3\' cleavage.

Aliases: BARD-1 antibody, Bard1 antibody, BARD1_HUMAN antibody, BRCA1 associated RING domain 1 antibody, BRCA1 associated RING domain gene 1 antibody, BRCA1 associated RING domain protein 1 antibody, BRCA1-associated RING domain protein 1 antibody

UniProt: Q99728

Pathways: DNA Reparatur