BAZ2A Antikörper (AA 97-266)

Produktnummer ABIN7145796

Produktdetails anti-BAZ2A Antikörper

Target: BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))

Bindungsspezifität: AA 97-266

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAZ2A Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Bromodomain adjacent to zinc finger domain protein 2A protein (97-266AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu BAZ2A

Target: BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))

Andere Bezeichnung: BAZ2A (BAZ2A Produkte)

Synonyme: zgc:101601 antikoerper, tip5 antikoerper, bax2a antikoerper, walp3 antikoerper, TIP5 antikoerper, WALp3 antikoerper, AA415431 antikoerper, C030005G16Rik antikoerper, C78388 antikoerper, Tip5 antikoerper, Walp3 antikoerper, mKIAA0314 antikoerper, bromodomain adjacent to zinc finger domain, 2A antikoerper, bromodomain adjacent to zinc finger domain 2A antikoerper, bromodomain adjacent to zinc finger domain 2A L homeolog antikoerper, Baz2a antikoerper, baz2a antikoerper, BAZ2A antikoerper, baz2a.L antikoerper

Hintergrund:

Background: Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on \\\'Lys-16\\\' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter, pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).

Aliases: BAZ2A antibody, KIAA0314 antibody, TIP5Bromodomain adjacent to zinc finger domain protein 2A antibody, Transcription termination factor I-interacting protein 5 antibody, TTF-I-interacting protein 5 antibody, Tip5 antibody, hWALp3 antibody

UniProt: Q9UIF9