BRD4 Antikörper (AA 150-200)

Produktnummer ABIN7145812

Produktdetails anti-BRD4 Antikörper

Target: BRD4 (Bromodomain Containing 4 (BRD4))

Bindungsspezifität: AA 150-200

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRD4 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Bromodomain-containing protein 4 protein (150-200AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu BRD4

Target: BRD4 (Bromodomain Containing 4 (BRD4))

Andere Bezeichnung: BRD4 (BRD4 Produkte)

Synonyme: brd4-b antikoerper, BRD4 antikoerper, fb18g03 antikoerper, wu:fb18g03 antikoerper, CAP antikoerper, HUNK1 antikoerper, HUNKI antikoerper, MCAP antikoerper, Brd5 antikoerper, WI-11513 antikoerper, bromodomain containing 4 L homeolog antikoerper, bromodomain containing 4 antikoerper, bromodomain-containing protein 4 antikoerper, brd4.L antikoerper, BRD4 antikoerper, brd4 antikoerper, LOC100409351 antikoerper, Brd4 antikoerper

Hintergrund:

Background: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters: BRD4 is required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II. Promotes phosphorylation of \\\'Ser-2\\\' of the C-terminal domain (CTD) of RNA polymerase II. According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of \\\'Ser-2\\\' of the C-terminal domain (CTD) of RNA polymerase II, these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B. Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters.

Aliases: Brd4 antibody, BRD4-NUT FUSION antibody, BRD4-NUT fusion oncoprotein antibody, BRD4_HUMAN antibody, Bromodomain containing 4 antibody, bromodomain containing protein 4 antibody, Bromodomain-containing protein 4 antibody, CAP antibody, chromosome associated protein antibody, HUNK1 antibody, HUNKI antibody, MCAP antibody, Mitotic chromosome-associated protein antibody, Protein HUNK1 antibody

UniProt: O60885

Pathways: Chromatin Binding, SARS-CoV-2 Protein Interaktom