BRD7 Antikörper (AA 601-651) (Biotin)

Produktnummer ABIN7145817

Produktdetails anti-BRD7 Antikörper (Biotin)

Target: BRD7 (Bromodomain Containing 7 (BRD7))

Bindungsspezifität: AA 601-651

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRD7 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Bromodomain-containing protein 7 protein (601-651AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu BRD7

Target: BRD7 (Bromodomain Containing 7 (BRD7))

Andere Bezeichnung: BRD7 (BRD7 Produkte)

Synonyme: zgc:66347 antikoerper, wu:fc95f02 antikoerper, MGC79478 antikoerper, BRD7 antikoerper, BP75 antikoerper, CELTIX1 antikoerper, NAG4 antikoerper, Ptpn13ip antikoerper, bromodomain containing 7 L homeolog antikoerper, bromodomain containing 7 antikoerper, brd7.L antikoerper, brd7 antikoerper, BRD7 antikoerper, Brd7 antikoerper

Hintergrund:

Background: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at \\\'Tyr-216\\\'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at \\\'Lys-9\\\' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at \\\'Lys-382\\\', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.

Aliases: 75 kDa bromodomain protein antibody, BP75 antibody, BRD 7 antibody, BRD7 antibody, BRD7_HUMAN antibody, Bromodomain containing 7 antibody, bromodomain containing protein 7 antibody, Bromodomain-containing protein 7 antibody, CELTIX 1 antibody, CELTIX1 antibody, NAG4 antibody, Protein CELTIX-1 antibody

UniProt: Q9NPI1