KCTD6 Antikörper (AA 1-237) (Biotin)
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- Target Alle KCTD6 Antikörper anzeigen
- KCTD6 (Potassium Channel Tetramerisation Domain Containing 6 (KCTD6))
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Bindungsspezifität
- AA 1-237
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser KCTD6 Antikörper ist konjugiert mit Biotin
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Applikation
- ELISA
- Kreuzreaktivität
- Human
- Aufreinigung
- >95%, Protein G purified
- Immunogen
- Recombinant Human BTB/POZ domain-containing protein KCTD6 protein (1-237AA)
- Isotyp
- IgG
- Top Product
- Discover our top product KCTD6 Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- KCTD6 (Potassium Channel Tetramerisation Domain Containing 6 (KCTD6))
- Andere Bezeichnung
- KCTD6 (KCTD6 Produkte)
- Synonyme
- KCTD6 antikoerper, 5430433B02Rik antikoerper, AU044285 antikoerper, kctd6 antikoerper, zgc:91884 antikoerper, KCASH3 antikoerper, potassium channel tetramerization domain containing 6 antikoerper, potassium channel tetramerisation domain containing 6 antikoerper, potassium channel tetramerization domain containing 6b antikoerper, KCTD6 antikoerper, kctd6 antikoerper, Kctd6 antikoerper, kctd6b antikoerper
- Hintergrund
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Background: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1, the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1, the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887).
Aliases: BTB/POZ domain-containing protein KCTD6 antibody, KCASH3 antibody, kctd6 antibody, KCTD6_HUMAN antibody, MGC27385 antibody, potassium channel tetramerization domain containing 6 antibody
- UniProt
- Q8NC69
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