CALHM1 Antikörper (AA 202-346)

Produktnummer ABIN7146297

Der Kaninchen Polyklonal Anti-CALHM1-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, CALHM1 in Proben von Human zu detektieren.

Kurzübersicht für CALHM1 Antikörper (AA 202-346) (ABIN7146297)

Target: CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CALHM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-CALHM1 Antikörper

Bindungsspezifität: AA 202-346

Kreuzreaktivität: Human, Maus

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Calcium homeostasis modulator protein 1 protein (202-346AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CALHM1

Target: CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))

Andere Bezeichnung: CALHM1

Hintergrund:

Background: Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca2+ concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca2+, Na+ and K+, as well as permeation of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca2+ dependent manner.

Aliases: CAHM1_HUMAN antibody, Calcium homeostasis modulator 1 antibody, Calcium homeostasis modulator protein 1 antibody, CALHM1 antibody, FAM26C antibody, Family with sequence similarity 26, member C antibody, MGC39514 antibody, MGC39617 antibody, OTTHUMP00000020413 antibody, Protein FAM26C antibody

UniProt: Q8IU99