CALCOCO2 Antikörper (AA 137-446)

Produktnummer ABIN7146349

Produktdetails anti-CALCOCO2 Antikörper

Target: CALCOCO2 (Calcium Binding and Coiled-Coil Domain 2 (CALCOCO2))

Bindungsspezifität: AA 137-446

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CALCOCO2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Calcium-binding and coiled-coil domain-containing protein 2 protein (137-446AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CALCOCO2

Target: CALCOCO2 (Calcium Binding and Coiled-Coil Domain 2 (CALCOCO2))

Andere Bezeichnung: CALCOCO2 (CALCOCO2 Produkte)

Synonyme: CALCOCO2 antikoerper, MGC110205 antikoerper, wu:fj08c01 antikoerper, zgc:110205 antikoerper, DKFZp469D2219 antikoerper, NDP52 antikoerper, 2410154J16Rik antikoerper, C77254 antikoerper, Ndp52 antikoerper, Ndp52l1 antikoerper, RGD1559974 antikoerper, calcium binding and coiled-coil domain 2 antikoerper, CALCOCO2 antikoerper, calcoco2 antikoerper, Calcoco2 antikoerper

Hintergrund:

Background: Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting galectin-8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994).

Aliases: Antigen nuclear dot 52 kDa protein antibody, CACO2_HUMAN antibody, Calcium binding and coiled coil domain 2 antibody, Calcium binding and coiled coil domain containing protein 2 antibody, Calcium-binding and coiled-coil domain-containing protein 2 antibody, CALCOCO 2 antibody, CALCOCO2 antibody, MGC17318 antibody, NDP52 antibody, Nuclear domain 10 protein 52 antibody, Nuclear domain 10 protein antibody, Nuclear domain 10 protein NDP52 antibody, Nuclear domain protein 52 antibody, Nuclear dot protein 52 antibody, OTTHUMP00000218344 antibody, OTTHUMP00000218345 antibody, OTTHUMP00000218346 antibody, OTTHUMP00000218347 antibody, OTTHUMP00000218349 antibody, OTTHUMP00000218351 antibody

UniProt: Q13137