CETN2 Antikörper (AA 1-172) (FITC)

Produktnummer ABIN7147355

Produktdetails anti-CETN2 Antikörper (FITC)

Target: CETN2 (Centrin, EF-Hand Protein, 2 (CETN2))

Bindungsspezifität: AA 1-172

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CETN2 Antikörper ist konjugiert mit FITC

Applikation: Bitte anfragen

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Centrin-2 protein (1-172AA)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CETN2

Target: CETN2 (Centrin, EF-Hand Protein, 2 (CETN2))

Andere Bezeichnung: CETN2 (CETN2 Produkte)

Synonyme: cb732 antikoerper, CETN2 antikoerper, 1110034A02Rik antikoerper, AI326150 antikoerper, Calt antikoerper, caltractin antikoerper, CALT antikoerper, CEN2 antikoerper, caltractin antikoerper, centrin 2 antikoerper, centrin 4 antikoerper, LOC412449 antikoerper, CETN2 antikoerper, cetn4 antikoerper, Cetn2 antikoerper

Hintergrund:

Background: Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.RInvolved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5\'-to-3\' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.

Aliases: 20kD calcium binding protein antibody, CALT antibody, caltractin antibody, Caltractin isoform 1 antibody, CEN2 antibody, centrin antibody, centrin, EF hand protein, 2 antibody, Centrin-2 antibody, Centrin2 antibody, CETN2 antibody, CETN2_HUMAN antibody, EF hand protein 2 antibody, EF-hand protein antibody

UniProt: P41208

Pathways: DNA Reparatur, M Phase