COPS3 Antikörper (AA 194-423)

Produktnummer ABIN7148495

Produktdetails anti-COPS3 Antikörper

Target: COPS3 (COP9 Signalosome Complex Subunit 3 (COPS3))

Bindungsspezifität: AA 194-423

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COPS3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Kreuzreaktivität: Human, Maus

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human COP9 signalosome complex subunit 3 protein (194-423AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu COPS3

Target: COPS3 (COP9 Signalosome Complex Subunit 3 (COPS3))

Andere Bezeichnung: COPS3 (COPS3 Produkte)

Hintergrund:

Background: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Aliases: Constitutive photomorphogenic homolog subunit 3 antibody, COP 9 (constitutive photomorphogenic) subunit 3 antibody, COP 9 complex homolog subunit 3 antibody, COP 9 complex S3 antibody, COP 9 complex subunit 3 antibody, COP 9 constitutive photomorphogenic homolog subunit 3 antibody, COP 9 homolog antibody, COP 9 signalosome complex subunit 3 antibody, COP 9 signalosome subunit 3 antibody, COP 9 subunit 3 antibody, COP9 (constitutive photomorphogenic) subunit 3 antibody, COP9 complex homolog subunit 3 antibody, COP9 complex S3 antibody, COP9 complex subunit 3 antibody, COP9 constitutive photomorphogenic homolog subunit 3 antibody, COP9 homolog antibody, COP9 signalosome complex subunit 3 antibody, COP9 signalosome subunit 3 antibody, COP9 subunit 3 antibody, COPS 3 antibody, cops3 antibody, CSN 3 antibody, CSN3 antibody, CSN3_HUMAN antibody, JAB 1 containing signalosome subunit 3 antibody, JAB1 containing signalosome subunit 3 antibody, JAB1-containing signalosome subunit 3 antibody, SGN 3 antibody, SGN3 antibody, Signalosome subunit 3 antibody

UniProt: Q9UNS2

Pathways: Zellzyklus