COPS7A Antikörper (AA 1-275)

Produktnummer ABIN7148498

Produktdetails anti-COPS7A Antikörper

Target: COPS7A (COP9 Signalosome Complex Subunit 7a (COPS7A))

Bindungsspezifität: AA 1-275

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COPS7A Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human COP9 signalosome complex subunit 7a protein (1-275AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu COPS7A

Target: COPS7A (COP9 Signalosome Complex Subunit 7a (COPS7A))

Andere Bezeichnung: COPS7A (COPS7A Produkte)

Synonyme: D6Ertd35e antikoerper, CSN7A antikoerper, COP9 signalosome subunit 7A antikoerper, COPS7A antikoerper, Cops7a antikoerper

Hintergrund:

Background: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Aliases: COP9 complex subunit 7a antibody, COP9 constitutive photomorphogenic homolog subunit 7A antibody, COP9 signalosome complex subunit 7a antibody, COP9 signalosome subunit 7A antibody, COPS7A antibody, CSN7A antibody, CSN7A_HUMAN antibody, Dermal papilla derived protein 10 antibody, Dermal papilla-derived protein 10 antibody, DERP10 antibody, JAB1 containing signalosome subunit 7a antibody, JAB1-containing signalosome subunit 7a antibody, SGN7a antibody, Signalosome subunit 7a antibody

UniProt: Q9UBW8

Pathways: Zellzyklus