CKAP5 Antikörper (AA 1802-2019) (HRP)

Produktnummer ABIN7149371

Produktdetails anti-CKAP5 Antikörper (HRP)

Target: CKAP5 (Cytoskeleton Associated Protein 5 (CKAP5))

Bindungsspezifität: AA 1802-2019

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CKAP5 Antikörper ist konjugiert mit HRP

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Cytoskeleton-associated protein 5 protein (1802-2019AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu CKAP5

Target: CKAP5 (Cytoskeleton Associated Protein 5 (CKAP5))

Andere Bezeichnung: CKAP5 (CKAP5 Produkte)

Hintergrund:

Background: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448).

Aliases: CKAP5 antibody, KIAA0097Cytoskeleton-associated protein 5 antibody, Colonic and hepatic tumor overexpressed gene protein antibody, Ch-TOG antibody

UniProt: Q14008

Pathways: M Phase