DPPA3 Antikörper (AA 1-159)

Produktnummer ABIN7149820

Produktdetails anti-DPPA3 Antikörper

Target: DPPA3 (Developmental Pluripotency Associated 3 (DPPA3))

Bindungsspezifität: AA 1-159

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DPPA3 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Developmental pluripotency-associated protein 3 protein (1-159AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:200-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu DPPA3

Target: DPPA3 (Developmental Pluripotency Associated 3 (DPPA3))

Andere Bezeichnung: DPPA3 (DPPA3 Produkte)

Synonyme: STELLA antikoerper, 2410075G02Rik antikoerper, PCG7 antikoerper, PGC7 antikoerper, Stella antikoerper, developmental pluripotency associated 3 antikoerper, developmental pluripotency-associated 3 antikoerper, DPPA3 antikoerper, Dppa3 antikoerper

Hintergrund:

Background: Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at \\\'Lys-9\\\' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis (By similarity).

Aliases: Compaction associated protein 1 antibody, Developmental pluripotency associated 3 antibody, Developmental pluripotency associated protein 3 antibody, Developmental pluripotency-associated protein 3 antibody, Dppa3 antibody, DPPA3_HUMAN antibody, PGC7 antibody, Stella related protein antibody, Stella-related protein antibody

UniProt: Q6W0C5