DLG5 Antikörper (AA 1580-1704)

Produktnummer ABIN7150080

Produktdetails anti-DLG5 Antikörper

Target: DLG5 (Discs, Large Homolog 5 (DLG5))

Bindungsspezifität: AA 1580-1704

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DLG5 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Disks large homolog 5 protein (1580-1704AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu DLG5

Target: DLG5 (Discs, Large Homolog 5 (DLG5))

Andere Bezeichnung: DLG5 (DLG5 Produkte)

Synonyme: DLG5 antikoerper, dlg5 antikoerper, wu:fc28f03 antikoerper, LP-DLG antikoerper, P-DLG5 antikoerper, PDLG antikoerper, 4933429D20Rik antikoerper, T25557 antikoerper, mKIAA0583 antikoerper, discs large MAGUK scaffold protein 5 antikoerper, discs, large homolog 5 (Drosophila) antikoerper, discs, large homolog 5a (Drosophila) antikoerper, DLG5 antikoerper, dlg5a antikoerper, Dlg5 antikoerper

Hintergrund:

Background: Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons, regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).

Aliases: Discs large homolog 5 (Drosophila) antibody, Discs large homolog 5 antibody, Discs large protein LP DLG antibody, Discs large protein P dlg antibody, Discs large protein P-dlg antibody, Disks large homolog 5 antibody, DLG 5 antibody, DLG5 antibody, DLG5_HUMAN antibody, KIAA0583 antibody, Large type of P DLG antibody, LP DLG antibody, P DLG5 antibody, PDLG antibody, Placenta and prostate DLG antibody

UniProt: Q8TDM6