DNA2 Antikörper (AA 1-300)

Produktnummer ABIN7150306

Produktdetails anti-DNA2 Antikörper

Target: DNA2 (DNA Replication Helicase 2 Homolog (DNA2))

Bindungsspezifität: AA 1-300

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DNA2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human DNA replication ATP-dependent helicase/nuclease DNA2 protein (1-300AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu DNA2

Target: DNA2 (DNA Replication Helicase 2 Homolog (DNA2))

Andere Bezeichnung: DNA2 (DNA2 Produkte)

Synonyme: DNA2L antikoerper, Dna2l antikoerper, E130315B21Rik antikoerper, PEOA6 antikoerper, hDNA2 antikoerper, XDna2 antikoerper, dna2-A antikoerper, DNA replication helicase/nuclease 2 antikoerper, DNA replication helicase/nuclease 2 S homeolog antikoerper, DNA2 antikoerper, Dna2 antikoerper, dna2.S antikoerper

Hintergrund:

Background: Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5\'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5\'-ssDNA, while the 3\'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5\'-3\' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5\'-3\' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function.

Aliases: DNA replication ATP-dependent helicase-like homolog antibody, DNA replication helicase 2 homolog antibody, DNA replication helicase 2, yeast, homolog of antibody, DNA replication helicase 2-like antibody, DNA replication helicase/nuclease 2 antibody, DNA2 antibody, DNA2-like helicase antibody, DNA2L antibody, DNA2L_HUMAN antibody, HDNA2 antibody, KIAA0083 antibody, PEOA6 antibody, SCKL8 antibody

UniProt: P51530

Pathways: Telomere Maintenance, DNA Reparatur, DNA Replication, Synthesis of DNA