DNA2 Antikörper (AA 1-300) (HRP)
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- Target Alle DNA2 Antikörper anzeigen
- DNA2 (DNA Replication Helicase 2 Homolog (DNA2))
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Bindungsspezifität
- AA 1-300
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser DNA2 Antikörper ist konjugiert mit HRP
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Applikation
- ELISA
- Kreuzreaktivität
- Human
- Aufreinigung
- >95%, Protein G purified
- Immunogen
- Recombinant Human DNA replication ATP-dependent helicase/nuclease DNA2 protein (1-300AA)
- Isotyp
- IgG
- Top Product
- Discover our top product DNA2 Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- DNA2 (DNA Replication Helicase 2 Homolog (DNA2))
- Andere Bezeichnung
- DNA2 (DNA2 Produkte)
- Synonyme
- DNA2L antikoerper, Dna2l antikoerper, E130315B21Rik antikoerper, PEOA6 antikoerper, hDNA2 antikoerper, XDna2 antikoerper, dna2-A antikoerper, DNA replication helicase/nuclease 2 antikoerper, DNA replication helicase/nuclease 2 S homeolog antikoerper, DNA2 antikoerper, Dna2 antikoerper, dna2.S antikoerper
- Hintergrund
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Background: Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5\'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5\'-ssDNA, while the 3\'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5\'-3\' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5\'-3\' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function.
Aliases: DNA replication ATP-dependent helicase-like homolog antibody, DNA replication helicase 2 homolog antibody, DNA replication helicase 2, yeast, homolog of antibody, DNA replication helicase 2-like antibody, DNA replication helicase/nuclease 2 antibody, DNA2 antibody, DNA2-like helicase antibody, DNA2L antibody, DNA2L_HUMAN antibody, HDNA2 antibody, KIAA0083 antibody, PEOA6 antibody, SCKL8 antibody
- UniProt
- P51530
- Pathways
- Telomere Maintenance, DNA Reparatur, DNA Replication, Synthesis of DNA
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