NDEL1 Antikörper (pSer242)

Produktnummer ABIN710816

Produktdetails anti-NDEL1 Antikörper

Target: NDEL1 (NudE Nuclear Distribution E Homolog (A. Nidulans)-Like 1 (NDEL1))

Bindungsspezifität: pSer242

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NDEL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus

Homologie: Rat,Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human NDEL1 around the phosphorylation site of Ser242

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu NDEL1

Target: NDEL1 (NudE Nuclear Distribution E Homolog (A. Nidulans)-Like 1 (NDEL1))

Andere Bezeichnung: NDEL1 (NDEL1 Produkte)

Synonyme: EOPA antikoerper, MITAP1 antikoerper, NDE1L1 antikoerper, NDE2 antikoerper, NUDEL antikoerper, NUDE2 antikoerper, Nudel antikoerper, 2600006O07Rik antikoerper, mNudel antikoerper, wu:fi23c04 antikoerper, wu:fi23e06 antikoerper, eopa antikoerper, mitap1 antikoerper, ndel1 antikoerper, ndel1-a antikoerper, ndel1-b antikoerper, nudel antikoerper, nudE neurodevelopment protein 1 like 1 antikoerper, nudE neurodevelopment protein 1-like 1 antikoerper, nudE neurodevelopment protein 1-like 1b antikoerper, nudE neurodevelopment protein 1 like 1 L homeolog antikoerper, NDEL1 antikoerper, Ndel1 antikoerper, ndel1b antikoerper, ndel1.L antikoerper

Hintergrund:

Synonyms: EOPA, NDE2, NUDEL, MITAP1, NDE1L1, Nuclear distribution protein nudE-like 1, Protein Nudel, Mitosin-associated protein 1, NDEL1

Background: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.

Gen-ID: 81565

UniProt: Q9GZM8

Pathways: Regulation of Cell Size