NSMCE2 Antikörper (AA 1-247)

Produktnummer ABIN7150959

Produktdetails anti-NSMCE2 Antikörper

Target: NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))

Bindungsspezifität: AA 1-247

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NSMCE2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human E3 SUMO-protein ligase NSE2 protein (1-247AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:500-1:1000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu NSMCE2

Target: NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))

Andere Bezeichnung: NSMCE2 (NSMCE2 Produkte)

Synonyme: 1110014D18Rik antikoerper, AI661537 antikoerper, RGD1305156 antikoerper, C8orf36 antikoerper, MMS21 antikoerper, NSE2 antikoerper, ZMIZ7 antikoerper, Non-SMC element 2 antikoerper, NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase antikoerper, NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase L homeolog antikoerper, Smc5-6 complex non-SMC subunit 2 antikoerper, Nsmce2 antikoerper, NSMCE2 antikoerper, nsmce2.L antikoerper, nse2 antikoerper

Hintergrund:

Background: E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression.

Aliases: C8orf36 antibody, E3 SUMO-protein ligase NSE2 antibody, hMMS21 antibody, hNSE2 antibody, methyl methanesulfonate sensitivity gene 21 antibody, MMS21 antibody, MMS21 homolog antibody, non-SMC element 2 antibody, Non-SMC element 2 homolog antibody, Non-structural maintenance of chromosomes element 2 homolog antibody, NSE2 antibody, NSE2_HUMAN antibody, Nsmce2 antibody

UniProt: Q96MF7