RNF2 Antikörper (AA 1-100)

Produktnummer ABIN7150987

Produktdetails anti-RNF2 Antikörper

Target: RNF2 (Ring Finger Protein 2 (RNF2))

Bindungsspezifität: AA 1-100

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNF2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase BRE1A protein (1-100AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RNF2

Target: RNF2 (Ring Finger Protein 2 (RNF2))

Andere Bezeichnung: RNF2 (RNF2 Produkte)

Synonyme: BAP-1 antikoerper, BAP1 antikoerper, DING antikoerper, HIPI3 antikoerper, RING1B antikoerper, RING2 antikoerper, AI326319 antikoerper, AI450156 antikoerper, AU019207 antikoerper, Ring1B antikoerper, dinG antikoerper, fa19h05 antikoerper, ring1b antikoerper, wu:fa19h05 antikoerper, wz4556 antikoerper, bap-1 antikoerper, bap1 antikoerper, ding antikoerper, hipi3 antikoerper, ring2 antikoerper, ring finger protein 2 antikoerper, ring finger protein 2 L homeolog antikoerper, RNF2 antikoerper, Rnf2 antikoerper, rnf2 antikoerper, rnf2.L antikoerper

Hintergrund:

Background: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of \\\'Lys-120\\\' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 \\\'Lys-4\\\' and \\\'Lys-79\\\' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B, reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.

Aliases: BRE1 A antibody, BRE1 antibody, BRE1 E3 ubiquitin ligase homolog antibody, BRE1-A antibody, BRE1A antibody, BRE1A_HUMAN antibody, E3 ubiquitin-protein ligase BRE1A antibody, hBRE1 antibody, Homolog of S. cerevisiae BRE1 antibody, RING finger protein 20 antibody, Ring finger protein 20 E3 ubiquitin protein ligase antibody, Rnf20 antibody

UniProt: Q5VTR2