STUB1 Antikörper (AA 1-48)

Produktnummer ABIN7151009

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch STUB1 in WB, ELISA, IHC und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für STUB1 Antikörper (AA 1-48) (ABIN7151009)

Target: STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STUB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-STUB1 Antikörper

Bindungsspezifität: AA 1-48

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase CHIP protein (1-48AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu STUB1

Target: STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))

Andere Bezeichnung: STUB1

Hintergrund:

Background: E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at \\\'Lys-41\\\', \\\'Lys-61\\\' and \\\'Lys-81\\\', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223).

Aliases: Antigen NY CO 7 antibody, Antigen NY-CO-7 antibody, C terminus of Hsp70-interacting protein antibody, Carboxy terminus of Hsp70 interacting protein antibody, Carboxy terminus of Hsp70-interacting protein antibody, Carboxy terminus of Hsp70p interacting protein antibody, CHIP antibody, CHIP_HUMAN antibody, CLL associated antigen KW 8 antibody, CLL-associated antigen KW-8 antibody, E3 ubiquitin protein ligase CHIP antibody, E3 ubiquitin-protein ligase CHIP antibody, Heat shock protein A binding protein 2 (c terminal) antibody, HSPABP2 antibody, NY CO 7 antibody, PP1131 antibody, SDCCAG7 antibody, Serologically defined colon cancer antigen 7 antibody, STIP1 homology and U Box containing protein 1 antibody, STIP1 homology and U box containing protein 1 E3 ubiquitin protein ligase antibody, STIP1 homology and U box-containing protein 1 antibody, STUB 1 antibody, STUB1 antibody, UBOX 1 antibody, UBOX1 antibody

UniProt: Q9UNE7

Pathways: Regulation of Hormone Metabolic Process, Response to Water Deprivation