MYLIP Antikörper (AA 266-445)

Produktnummer ABIN7151077

Produktdetails anti-MYLIP Antikörper

Target: MYLIP (Myosin Regulatory Light Chain Interacting Protein (MYLIP))

Bindungsspezifität: AA 266-445

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MYLIP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Kreuzreaktivität: Human, Maus

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase MYLIP protein (266-445AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu MYLIP

Target: MYLIP (Myosin Regulatory Light Chain Interacting Protein (MYLIP))

Andere Bezeichnung: MYLIP (MYLIP Produkte)

Synonyme: IDOL antikoerper, MIR antikoerper, 9430057C20Rik antikoerper, Mir antikoerper, mylip antikoerper, wu:fj36b03 antikoerper, zgc:55987 antikoerper, MYLIP antikoerper, mir antikoerper, zgc:153767 antikoerper, myosin regulatory light chain interacting protein antikoerper, myosin regulatory light chain interacting protein a antikoerper, myosin regulatory light chain interacting protein L homeolog antikoerper, myosin regulatory light chain interacting protein b antikoerper, MYLIP antikoerper, Mylip antikoerper, mylipa antikoerper, mylip.L antikoerper, mylip antikoerper, mylipb antikoerper

Hintergrund:

Background: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

Aliases: BM-023 antibody, BZF1 antibody, E3 ubiquitin protein ligase MYLIP antibody, E3 ubiquitin-protein ligase MYLIP antibody, Idol antibody, Inducible degrader of the LDL-receptor antibody, Lipoprotein receptor antibody, MIR antibody, MYLIP antibody, MYLIP_HUMAN antibody, Myosin regulatory light chain interacting protein antibody, PP5242 antibody

UniProt: Q8WY64