NHLRC1 Antikörper (AA 1-280)

Produktnummer ABIN7151086

Produktdetails anti-NHLRC1 Antikörper

Target: NHLRC1 (NHL Repeat Containing 1 (NHLRC1))

Bindungsspezifität: AA 1-280

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NHLRC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Human, Ratte

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase NHLRC1 protein (1-280AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu NHLRC1

Target: NHLRC1 (NHL Repeat Containing 1 (NHLRC1))

Andere Bezeichnung: NHLRC1 (NHLRC1 Produkte)

Synonyme: EPM2A antikoerper, EPM2B antikoerper, MALIN antikoerper, bA204B7.2 antikoerper, AI505271 antikoerper, B230309E09Rik antikoerper, Epm2b antikoerper, malin-like antikoerper, NHL repeat containing E3 ubiquitin protein ligase 1 antikoerper, NHL repeat containing 1 antikoerper, NHLRC1 antikoerper, Nhlrc1 antikoerper

Hintergrund:

Background: E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.

Aliases: bA204B7.2 antibody, E3 ubiquitin-protein ligase NHLRC1 antibody, EPM2A antibody, EPM2B antibody, EPM2B gene antibody, Malin antibody, MGC119262 antibody, MGC119264 antibody, MGC119265 antibody, NHL repeat containing 1 antibody, NHL repeat containing E3 ubiquitin protein ligase 1 antibody, NHL repeat containing protein 1 antibody, NHL repeat-containing protein 1 antibody, NHL repeat-containing protein 1 gene antibody, NHLC1_HUMAN antibody, NHLRC 1 antibody, Nhlrc1 antibody

UniProt: Q6VVB1