RNF126 Antikörper (AA 39-225) (Biotin)

Produktnummer ABIN7151135

Produktdetails anti-RNF126 Antikörper (Biotin)

Target: RNF126 (Ring Finger Protein 126 (RNF126))

Bindungsspezifität: AA 39-225

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNF126 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase RNF126 protein (39-225AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RNF126

Target: RNF126 (Ring Finger Protein 126 (RNF126))

Andere Bezeichnung: RNF126 (RNF126 Produkte)

Synonyme: 2610010O19Rik antikoerper, ring finger protein 126 antikoerper, RNF126 antikoerper, Rnf126 antikoerper

Hintergrund:

Background: E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates \'Lys-48\'- and \'Lys-63\'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).

Aliases: E3 ubiquitin-protein ligase RNF126 antibody, FLJ20552 antibody, MGC1022 antibody, MGC14317 antibody, RING finger protein 126 antibody, RN126_HUMAN antibody, RNF 126 antibody, RNF126 antibody

UniProt: Q9BV68