RNF128 Antikörper (AA 229-400)
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- Target Alle RNF128 Antikörper anzeigen
- RNF128 (Ring Finger Protein 128 (RNF128))
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Bindungsspezifität
- AA 229-400
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser RNF128 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunofluorescence (IF)
- Kreuzreaktivität
- Human, Maus
- Aufreinigung
- >95%, Protein G purified
- Immunogen
- Recombinant Human E3 ubiquitin-protein ligase RNF128 protein (229-400AA)
- Isotyp
- IgG
- Top Product
- Discover our top product RNF128 Primärantikörper
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- Applikationshinweise
- Recommended dilution: WB:1:1000-1:5000, IF:1:50-1:200,
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- RNF128 (Ring Finger Protein 128 (RNF128))
- Andere Bezeichnung
- RNF128 (RNF128 Produkte)
- Hintergrund
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Background: E3 ubiquitin-protein ligase that catalyzes \\\'Lys-48\\\'- and \\\'Lys-63\\\'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with \\\'Lys-48\\\' linkages and COR1A with \\\'Lys-63\\\' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm, sensitizes ectoderm to respond to neural-inducing signals.
Aliases: E3 ubiquitin protein ligase RNF128 antibody, E3 ubiquitin-protein ligase RNF128 antibody, FLJ23516 antibody, Gene related to anergy in lymphocytes protein antibody, GRAIL antibody, RING finger protein 128 antibody, RN128_HUMAN antibody, RNF128 antibody
- UniProt
- Q8TEB7
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