RNF128 Antikörper (AA 229-400) (Biotin)

Produktnummer ABIN7151139

Produktdetails anti-RNF128 Antikörper (Biotin)

Target: RNF128 (Ring Finger Protein 128 (RNF128))

Bindungsspezifität: AA 229-400

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNF128 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase RNF128 protein (229-400AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RNF128

Target: RNF128 (Ring Finger Protein 128 (RNF128))

Andere Bezeichnung: RNF128 (RNF128 Produkte)

Synonyme: rnf128 antikoerper, wu:fb57h05 antikoerper, zgc:77843 antikoerper, 1300002C13Rik antikoerper, AI987883 antikoerper, GRAIL antikoerper, Greul1 antikoerper, RGD1566282 antikoerper, grail antikoerper, greul1 antikoerper, ring finger protein 128a antikoerper, ring finger protein 128, E3 ubiquitin protein ligase antikoerper, ring finger protein 128 antikoerper, ring finger protein 128, E3 ubiquitin protein ligase L homeolog antikoerper, rnf128a antikoerper, RNF128 antikoerper, Rnf128 antikoerper, rnf128.L antikoerper

Hintergrund:

Background: E3 ubiquitin-protein ligase that catalyzes \'Lys-48\'- and \'Lys-63\'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with \'Lys-48\' linkages and COR1A with \'Lys-63\' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm, sensitizes ectoderm to respond to neural-inducing signals.

Aliases: E3 ubiquitin protein ligase RNF128 antibody, E3 ubiquitin-protein ligase RNF128 antibody, FLJ23516 antibody, Gene related to anergy in lymphocytes protein antibody, GRAIL antibody, RING finger protein 128 antibody, RN128_HUMAN antibody, RNF128 antibody

UniProt: Q8TEB7