RNF4 Antikörper (AA 1-103) (Biotin)

Produktnummer ABIN7151195

Produktdetails anti-RNF4 Antikörper (Biotin)

Target: RNF4 (Ring Finger Protein 4 (RNF4))

Bindungsspezifität: AA 1-103

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNF4 Antikörper ist konjugiert mit Biotin

Applikation: ELISA

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase RNF4 protein (1-103AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RNF4

Target: RNF4 (Ring Finger Protein 4 (RNF4))

Andere Bezeichnung: RNF4 (RNF4 Produkte)

Synonyme: SLX5 antikoerper, SNURF antikoerper, AU018689 antikoerper, Gtrgeo8 antikoerper, ring finger protein 4 antikoerper, RNF4 antikoerper, Rnf4 antikoerper

Hintergrund:

Background: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates \'Lys-6\'-, \'Lys-11\'-, \'Lys-48\'- and \'Lys-63\'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.

Aliases: E3 ubiquitin ligase RNF4 antibody, E3 ubiquitin protein ligase RNF4 antibody, Protein SNURF antibody, RES4 26 antibody, RING finger protein 4 antibody, Rnf4 antibody, RNF4_HUMAN antibody, SLX5 antibody, Small nuclear ring finger protein antibody, SNURF antibody

UniProt: P78317

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway