SIAH2 Antikörper (AA 1-72)

Produktnummer ABIN7151218

Produktdetails anti-SIAH2 Antikörper

Target: SIAH2 (Siah E3 Ubiquitin Protein Ligase 2 (SIAH2))

Bindungsspezifität: AA 1-72

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIAH2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase SIAH2 protein (1-72AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:500-1:1000, IF:1:200-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SIAH2

Target: SIAH2 (Siah E3 Ubiquitin Protein Ligase 2 (SIAH2))

Andere Bezeichnung: SIAH2 (SIAH2 Produkte)

Synonyme: hSiah2 antikoerper, Xsiah-2 antikoerper, siah2-A antikoerper, xsiah2 antikoerper, AA415433 antikoerper, Sinh2 antikoerper, siah E3 ubiquitin protein ligase 2 antikoerper, siah E3 ubiquitin protein ligase 2 L homeolog antikoerper, seven in absentia 2 antikoerper, SIAH2 antikoerper, siah2.L antikoerper, Siah2 antikoerper

Hintergrund:

Background: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not. Promotes monoubiquitination of SNCA.

Aliases: E3 ubiquitin-protein ligase Siah2 antibody, hSiah2 antibody, Seven in absentia homolog 2 antibody, Siah E3 ubiquitin protein ligase 2 antibody, Siah-2 antibody, siah2 antibody, SIAH2_HUMAN antibody, Ubiquitin Ligase Siah2 antibody

UniProt: O43255