TRIM13 Antikörper (AA 40-310)

Produktnummer ABIN7151242

Produktdetails anti-TRIM13 Antikörper

Target: TRIM13 (Tripartite Motif Containing 13 (TRIM13))

Bindungsspezifität: AA 40-310

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIM13 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human E3 ubiquitin-protein ligase TRIM13 protein (40-310AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu TRIM13

Target: TRIM13 (Tripartite Motif Containing 13 (TRIM13))

Andere Bezeichnung: TRIM13 (TRIM13 Produkte)

Synonyme: TRIM13 antikoerper, RFP2 antikoerper, CAR antikoerper, DLEU5 antikoerper, LEU5 antikoerper, RNF77 antikoerper, 3110001L12Rik antikoerper, Rfp2 antikoerper, tripartite motif containing 13 antikoerper, ret finger protein 2 antikoerper, tripartite motif-containing 13 antikoerper, TRIM13 antikoerper, LOC100338599 antikoerper, Trim13 antikoerper

Hintergrund:

Background: E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor.

Aliases: B cell chronic lymphocytic leukemia tumor suppressor Leu5 antibody, B-cell chronic lymphocytic leukemia tumor suppressor Leu5 antibody, CAR antibody, DLEU5 antibody, E3 ubiquitin-protein ligase TRIM13 antibody, HGNC:9976 antibody, LEU5 antibody, Leukemia associated protein 5 antibody, Leukemia-associated protein 5 antibody, Putative tumor suppressor RFP2 antibody, Ret finger protein 2 antibody, RFP2 antibody, RING finger protein 77 antibody, RNF77 antibody, TRI13_HUMAN antibody, Trim13 antibody, Tripartite motif protein 13 antibody, Tripartite motif-containing protein 13 antibody

UniProt: O60858