EGLN1 Antikörper (AA 301-426)

Produktnummer ABIN7151443

Produktdetails anti-EGLN1 Antikörper

Target: EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))

Bindungsspezifität: AA 301-426

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EGLN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human, Ratte

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Egl nine homolog 1 protein (301-426AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu EGLN1

Target: EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))

Andere Bezeichnung: EGLN1 (EGLN1 Produkte)

Synonyme: EGLN1 antikoerper, egln2 antikoerper, phd2 antikoerper, zgc:92314 antikoerper, AI503754 antikoerper, C1orf12 antikoerper, HIF-PH2 antikoerper, HPH-2 antikoerper, Hif-p4h-2 antikoerper, ORF13 antikoerper, Phd2 antikoerper, SM-20 antikoerper, PHD-2 antikoerper, PHD2 antikoerper, ECYT3 antikoerper, HIFPH2 antikoerper, HPH2 antikoerper, SM20 antikoerper, ZMYND6 antikoerper, egl nine homolog 1 (C. elegans) antikoerper, egl-9 family hypoxia inducible factor 1 antikoerper, egl-9 family hypoxia-inducible factor 1 S homeolog antikoerper, egl-9 family hypoxia-inducible factor 1b antikoerper, egl-9 family hypoxia-inducible factor 1 antikoerper, EGLN1 antikoerper, egln1.S antikoerper, egln1b antikoerper, Egln1 antikoerper

Hintergrund:

Background: Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferencially recognized via a LXXLAP motif.

Aliases: C1ORF12 antibody, Chromosome 1 Open Reading Frame 12 antibody, DKFZp761F179 antibody, ECYT 3 antibody, ECYT3 antibody, Egl 9 family hypoxia inducible factor 1 antibody, EGL 9 homolog of C. elegans 1 antibody, EGL nine (C.elegans) homolog 1 antibody, Egl nine homolog 1 (C. elegans) antibody, Egl nine homolog 1 antibody, Egl nine like protein 1 antibody, EGLN 1 antibody, Egln1 antibody, EGLN1_HUMAN antibody, HIF PH2 antibody, HIF Prolyl Hydroxylase 2 antibody, HIF-PH2 antibody, HIF-prolyl hydroxylase 2 antibody, HIFP4H 2 antibody, HIFPH2 antibody, HPH 2 antibody, HPH-2 antibody, HPH2 antibody, Hypoxia inducible factor prolyl hydroxylase 2 antibody, Hypoxia-inducible factor prolyl hydroxylase 2 antibody, ORF13 antibody, P4H2 antibody, PHD 2 antibody, PhD2 antibody, PNAS 118 antibody, PNAS 137 antibody, Prolyl Hydroxylase Domain Containing Protein 2 antibody, Prolyl hydroxylase domain-containing protein 2 antibody, Rat Homolog of SM20 antibody, SM 20 antibody, SM-20 antibody, SM20 antibody, Zinc finger MYND domain containing protein 6 antibody, ZMYND6 antibody

UniProt: Q9GZT9

Pathways: cAMP Metabolic Process, Warburg Effekt