EPH Receptor A8 Antikörper (AA 45-249)

Produktnummer ABIN7151855

Produktdetails anti-EPH Receptor A8 Antikörper

Target: EPH Receptor A8 (EPHA8)

Bindungsspezifität: AA 45-249

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPH Receptor A8 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF)

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Ephrin type-A receptor 8 protein (45-249AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IF:1:50-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu EPH Receptor A8

Target: EPH Receptor A8 (EPHA8)

Andere Bezeichnung: EPHA8 (EPHA8 Produkte)

Synonyme: TK antikoerper, tke17-a antikoerper, si:ch211-122l14.1 antikoerper, EPHA8 antikoerper, EEK antikoerper, EK3 antikoerper, HEK3 antikoerper, AW047546 antikoerper, Eek antikoerper, Hek3 antikoerper, mKIAA1459 antikoerper, EPH receptor A8 L homeolog antikoerper, EPH receptor A8 antikoerper, eph receptor A8 antikoerper, Eph receptor A8 antikoerper, epha8.L antikoerper, EPHA8 antikoerper, epha8 antikoerper, Epha8 antikoerper

Hintergrund:

Background: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity).

Aliases: EPHA8 antibody, EEK antibody, HEK3 antibody, KIAA1459Ephrin type-A receptor 8 antibody, EC 2.7.10.1 antibody, EPH- and ELK-related kinase antibody, EPH-like kinase 3 antibody, EK3 antibody, hEK3 antibody, Tyrosine-protein kinase receptor EEK antibody

UniProt: P29322

Pathways: RTK Signalweg