EPH Receptor B1 Antikörper (AA 260-500)

Produktnummer ABIN7151859

Produktdetails anti-EPH Receptor B1 Antikörper

Target: EPH Receptor B1 (EPHB1)

Bindungsspezifität: AA 260-500

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPH Receptor B1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Ephrin type-B receptor 1 protein (260-500AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu EPH Receptor B1

Target: EPH Receptor B1 (EPHB1)

Andere Bezeichnung: EPHB1 (EPHB1 Produkte)

Synonyme: ELK antikoerper, EPHT2 antikoerper, Hek6 antikoerper, NET antikoerper, ephb1-a antikoerper, xek antikoerper, Xek antikoerper, MGC89790 antikoerper, EPHB1 antikoerper, CEK6 antikoerper, EK6 antikoerper, 9330129L11 antikoerper, AW488255 antikoerper, C130099E04Rik antikoerper, Cek6 antikoerper, ENSMUSG00000074119 antikoerper, Elk antikoerper, Elkh antikoerper, Net antikoerper, Ephb2 antikoerper, Erk antikoerper, elk antikoerper, EPH receptor B1 antikoerper, EPH receptor B1 S homeolog antikoerper, ephrin type-B receptor 1 antikoerper, Eph receptor B1 antikoerper, EPHB1 antikoerper, ephb1.S antikoerper, ephb1 antikoerper, LOC100467687 antikoerper, Ephb1 antikoerper

Hintergrund:

Background: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.

Aliases: Cek 6 antibody, EK6 antibody, ELK antibody, Elkh antibody, EPH receptor B1 antibody, Eph tyrosine kinase 2 antibody, EPH-like kinase 6 antibody, Ephb1 antibody, EPHB1_HUMAN antibody, Ephrin type B receptor 1 antibody, Ephrin type-B receptor 1 antibody, EPHT2 antibody, HEK 6 antibody, HEK6 antibody, NET antibody, Neuronally-expressed EPH-related tyrosine kinase antibody, soluble EPHB1 variant 1 antibody, Tyrosine protein kinase receptor EPH 2 antibody, Tyrosine-protein kinase receptor EPH-2 antibody

UniProt: P54762

Pathways: RTK Signalweg