FBXO6 Antikörper (AA 104-293)

Produktnummer ABIN7152447

Produktdetails anti-FBXO6 Antikörper

Target: FBXO6 (F-Box Protein 6 (FBXO6))

Bindungsspezifität: AA 104-293

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FBXO6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human F-box only protein 6 protein (104-293AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu FBXO6

Target: FBXO6 (F-Box Protein 6 (FBXO6))

Andere Bezeichnung: FBXO6 (FBXO6 Produkte)

Synonyme: FBG2 antikoerper, FBS2 antikoerper, FBX6 antikoerper, Fbx6b antikoerper, AA408845 antikoerper, Fbs2 antikoerper, Fbxo6b antikoerper, Fbg2 antikoerper, FBXO6 antikoerper, fbg2 antikoerper, fbs2 antikoerper, fbx6 antikoerper, fbx6b antikoerper, fbxo44 antikoerper, F-box protein 6 antikoerper, F-box protein 6 S homeolog antikoerper, FBXO6 antikoerper, Fbxo6 antikoerper, fbxo6.S antikoerper

Hintergrund:

Background: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on \\\'Ser-345\\\'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.

Aliases: F box protein that recognizes sugar chains 2 antibody, F box G domain protein 2 antibody, F box only protein 6 antibody, F box protein 6 antibody, F box protein FBG2 antibody, F box protein Fbx6 antibody, F box/G domain protein 2 antibody, F-box only protein 6 antibody, F-box protein that recognizes sugar chains 2 antibody, F-box/G-domain protein 2 antibody, FBG 2 antibody, FBG2 antibody, FBS 2 antibody, FBS2 antibody, FBX 6 antibody, FBX6 antibody, FBX6_HUMAN antibody, FBXO 6 antibody, FBXO6 antibody, OTTHUMP00000002267 antibody

UniProt: Q9NRD1