SUPT16H Antikörper (AA 187-282)

Produktnummer ABIN7152513

Produktdetails anti-SUPT16H Antikörper

Target: SUPT16H (FACT complex subunit SPT16 (SUPT16H))

Bindungsspezifität: AA 187-282

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SUPT16H Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human FACT complex subunit SPT16 protein (187-282AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu SUPT16H

Target: SUPT16H (FACT complex subunit SPT16 (SUPT16H))

Andere Bezeichnung: SUPT16H (SUPT16H Produkte)

Hintergrund:

Background: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of \'Ser-392\' of p53/TP53 via its association with CK2 (casein kinase II).

Aliases: CDC68 antibody, Chromatin specific transcription elongation factor 140 kDa subunit antibody, Chromatin-specific transcription elongation factor 140 kDa subunit antibody, Facilitates chromatin transcription complex subunit SPT16 antibody, FACT 140 kDa subunit antibody, FACT antibody, FACT complex subunit SPT16 antibody, FACTp140 antibody, FLJ10857 antibody, FLJ14010 antibody, hSPT16 antibody, SP16H_HUMAN antibody, Suppressor of Ty 16 homolog antibody, Supt16h antibody

UniProt: Q9Y5B9

Pathways: Chromatin Binding